Endocrine Abstracts

Weight regain after weight loss is a well described-phenomena in both humans and animal models of obesity and thought to be related to reduced energy expenditure and increased food intake. Reduced lipolysis in white adipose tissue has been described in obesity. We hypothesized that lipolytic defect in adipose tissue in the obese state persists after weight loss increasing efficiency of lipid storing and promotes weight regain. We utilized a mouse model of obesity memory (OM): ...